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Article

Gut Microbiome Mediates the Causal Link Between Autism Spectrum Disorder and Dietary Preferences: A Mendelian Randomization Study.

International journal of molecular sciences - 20 Feb 2026

Wu Yuqi, Wong Oscar W H, Chen Sizhe, Wang Yun, Zhang Guoqing, Gao Ying, Chan Francis K L, Ng Siew Chien, Su Qi

Abstract excerpt

Autism spectrum disorder (ASD) frequently co-occurs with malnutrition and gut dysbiosis, yet the underlying mechanisms remain poorly understood. Herein, this cross-sectional study first profiles dietary intake differences using dietary records from 210,874 participants (ASD = 232; non-ASD = 210,642; median age = 56.18) from the UK Biobank (UKB). Second, a bi-directional Mendelian Randomization (MR) approach...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41752141
DOI: 10.3390/ijms27042006
PMCID: PMC12941152

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PGC

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