Achieved LDL-C levels <55 mg/dL and cardiac events in patients and lesions harbouring lipid-rich plaque phenotypes.

doi:10.1093/ehjci/jeag057

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Article

Achieved LDL-C levels <55 mg/dL and cardiac events in patients and lesions harbouring lipid-rich plaque phenotypes.

European heart journal. Cardiovascular Imaging - 30 Apr 2026

Kataoka Yu, Nicholls Stephen J, Kiyoshige Eri, Nishimura Kunihiro, Puri Rishi, Kitahara Satoshi, Murai Kota, Mitsui Kentaro, Tomishima Yoshiyuki, Sawada Kenichiro, Matama Hideo, Iwai Takamasa, Honda Satoshi, Nakao Kazuhiro, Fujino Masashi, Takagi Kensuke, Yoneda Shuichi, Otsuka Fumiyuki, Nishihira Kensaku, Takamisawa Itaru, Asaumi Yasuhide, Noguchi Teruo

Abstract excerpt

AIMS: The European Society of Cardiology guidelines recommend low-density lipoprotein cholesterol (LDL-C) < 55 mg/dL in very-high-risk patients. Given that plaque phenotype underscores its modulatory response to lipid-lowering therapies, patients and lesions harbouring lipid-laden plaques may benefit from LDL-C < 55 mg/dL to reduce their cardiovascular risks. METHODS AND RESULTS: The REASSURE-NIRS (REvelation of...

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PMID: 41738355
DOI: 10.1093/ehjci/jeag057
PMCID: PMC13128272

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