From Sound to Stability: Lessons Learned From the CRUSH Study on Hearing Loss Progression and Vestibular Phenotype in Usher Syndrome Type 2A.

doi:10.1097/MAO.0000000000004851

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From Sound to Stability: Lessons Learned From the CRUSH Study on Hearing Loss Progression and Vestibular Phenotype in Usher Syndrome Type 2A.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology - 1 Apr 2026

Wijn Dirk H, Fehrmann Mirthe L A, Robijn Sybren M M, Velde Hedwig M, Smits Jeroen J, van Wijk Erwin, Beynon Andy J, Cals Froukje L J, Hoyng Carel B, Yzer Suzanne, Lanting Cris P, Pennings Ronald J E

Abstract excerpt

OBJECTIVE: This study aims to analyze the progression of hearing loss using prospectively collected data and describe the vestibular phenotype of Usher syndrome type 2A (USH 2a ). STUDY DESIGN: Longitudinal, prospective, observational natural history study. PATIENTS: Patients with USH2a and USH2A -associated non-syndromic retinitis pigmentosa (nsRP). MAIN OUTCOME MEASURES: Hearing loss progression was measured by...

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PMID: 41729786
DOI: 10.1097/MAO.0000000000004851
PMCID: PMC12970546

Genes

USH2A

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