Genetic Bases of Arthrogryposis Multiplex Congenita.

Abstract excerpt

Arthrogryposis multiplex congenita (AMC) is characterized by congenital joint contractures in two or more body areas resulting from reduced or absent fetal movements. AMC exhibits marked phenotypic and genetic heterogeneity, as it is a symptom rather than a disease and may be part of a large number of unrelated conditions. Despite advances in genomic approaches and the increasing number of newly identified genes,...

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• Arthrogryposis
• Genes, Recessive
• Genetic Heterogeneity
• Muscle, Skeletal
• Mutation
• Phenotype