Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heart rate variability: longitudinal cardioautonomic physiomarker in congenital central hypoventilation syndrome.

Annals of the American Thoracic Society - 1 Jun 2026

Gendler Joely R, Zhou Amy, Rand Casey M, Patout Maxime, Weese-Mayer Debra E, Krishnamurthi Narayanan

Abstract excerpt

RATIONALE: Congenital central hypoventilation syndrome (CCHS) is caused by PHOX2B gene variants, resulting in highly variable cardiac autonomic dysregulation, including abrupt sinus pauses and risk of sudden unexpected death. The relationship between age, PHOX2B genotype, and cardiac autonomic dysfunction remains unknown, and CCHS-related physiomarkers are lacking. OBJECTIVE: To assess the impact of age and...

Topics

Join the communities discussing this publication.

Autonomic Nervous System
Electrocardiography
Heart Rate
Homeodomain Proteins
Hypoventilation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Polysomnography

Sleep Apnea, Central

Source

Open in PubMed Open full text

Identifiers

PMID: 41721744
DOI: 10.1093/annalsats/aaoag027
PMCID: PMC13235852

Genes

PHOX2B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heart rate variability: longitudinal cardioautonomic physiomarker in congenital central hypoventilation syndrome.PMID 41721744Read ↗

Congenital central hypoventilation syndrome: PHOX2B genotype determines risk for sudden death.Semantic proximity Read ↗

An official ATS clinical policy statement: Congenital central hypoventilation syndrome: genetic basis, diagnosis, and management.Semantic proximity Read ↗

Congenital central hypoventilation syndrome: diagnosis and management.Semantic proximity Read ↗

International Congenital Central Hypoventilation Syndrome (CCHS) Registry: Analysis of Patient-Reported Symptoms by PHOX2B VariantSemantic proximity Read ↗

Vagal and sympathetic heart rate and blood pressure control in adult onset PHOX2B mutation-confirmed congenital central hypoventilation syndrome.Semantic proximity Read ↗

Central congenital hypoventilation syndrome: changing face of a less mysterious but more complex genetic disorder.Semantic proximity Read ↗

Congenital central hypoventilation syndrome: a bedside-to-bench success story for advancing early diagnosis and treatment and improved survival and quality of life.Semantic proximity Read ↗

Guidelines for diagnosis and management of congenital central hypoventilation syndrome.Semantic proximity Read ↗

Congenital central hypoventilation syndrome from past to future: model for translational and transitional autonomic medicine.Semantic proximity Read ↗

Life-threatening cardiac arrhythmias in congenital central hypoventilation syndrome.Semantic proximity Read ↗

Clinical practices and prognosis of Congenital Central Hypoventilation Syndrome : based on 20-year-records in KoreaSemantic proximity Read ↗

Congenital central hypoventilation syndrome in korea: 20 years of clinical observation and evaluation of the ventilation strategy in a single center.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.