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Article

REACH: C-cause.

Journal of Crohn's & colitis - 1 Feb 2026

Williams Stephanie, Meran Laween, McCartney Sara, Harrow Paul, Lee James C

Abstract excerpt

Inflammatory bowel disease (IBD) arises from a multifaceted interplay of genetic predisposition, environmental triggers, microbial dynamics, and immune dysregulation. This complex network of interacting factors disrupts gut homeostasis, leading to chronic relapsing inflammation in the gastrointestinal tract. This review synthesizes the current understanding of the multifactorial causes of IBD. Central to disease...

Topics

Humans
Inflammatory Bowel Diseases
Gastrointestinal Microbiome
Immunity, Innate
Adaptive Immunity
Genetic Predisposition to Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 41711045
DOI: 10.1093/ecco-jcc/jjaf222

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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