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Article

Genetic Insights into Circulating Complement Proteins in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Potential Inflammatory Subgroup.

International journal of molecular sciences - 5 Feb 2026

Maya Jessica, Unger Elizabeth R, Lin Jin-Mann S, Rajeevan Mangalathu S

Abstract excerpt

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating multi-system illness with heterogeneity that complicates identifying the pathophysiology, biomarkers, and therapeutic targets. Evidence indicates the importance of immune dysregulation, including the complement system, in ME/CFS. This study investigates the contribution of genetic drivers to potential dysregulation of the complement...

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Topics

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Share to Complement C3
Share to Complement System Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatigue Syndrome, Chronic

Share to C3 gene

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 41683992
DOI: 10.3390/ijms27031574
PMCID: PMC12898610

Genes

C3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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