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Article

Integrative modeling to improve bleeding risk prediction in adult female hemophilia A carriers.

Journal of thrombosis and haemostasis : JTH - 1 May 2026

Cygan Peter H, Weidman Elizabeth A, Wang Xi, Kong Lan, Eyster M Elaine, Carrel Laura

Abstract excerpt

BACKGROUND: Although bleeding phenotypes and factor (F)VIII activity (FVIII:C) in men with hemophilia A correlate highly with F8 mutations, FVIII:C in female HA carriers is more variable due to mosaicism arising from a second wild-type F8 allele and X-chromosome inactivation (XCI). Conventionally, only female HA carriers with low FVIII:C were considered at risk for bleeding. However, hemostatic FVIII:C levels in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41679506
DOI: 10.1016/j.jtha.2026.01.015
PMCID: PMC13033278

Genes

F8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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