Microbiota humanization drives human‐like metabolic and immune transcriptomic shifts in pigs

Abstract excerpt

Abstract Pigs are increasingly recognized as promising candidates for clinical xenotransplantation and as large‐animal models for biomedical research; however, interspecies differences in gut microbiota, immune function, and metabolism remain major barriers. To address this, we established gut microbiota‐humanized (GMH) pigs by transplanting human fecal microbiota into antibiotic‐treated pigs. We systemically...