Patient-reported outcomes and time to symptomatic progression from PAPILLON: amivantamab plus chemotherapy vs chemotherapy as first-line treatment of EGFR exon 20 insertion-mutated advanced NSCLC.

doi:10.1016/j.lungcan.2025.108788

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Patient-reported outcomes and time to symptomatic progression from PAPILLON: amivantamab plus chemotherapy vs chemotherapy as first-line treatment of EGFR exon 20 insertion-mutated advanced NSCLC.

Lung cancer (Amsterdam, Netherlands) - 1 Mar 2026

Paz-Ares Luis, Veillon Remi, Majem Margarita, Zhou Caicun, Tang Ke-Jing, Kim Sang-We, Richardson Gary, Girard Nicolas, Sanborn Rachel E, Mansfield Aaron S, Park Keunchil, Schuchard Julia, Diels Joris, Sermon Jan, Bhattacharya Archan, Lorenzini Patricia, Wortman-Vayn Honeylet, Knoblauch Roland E, Agrawal Trishala, Baig Mahadi, Ono Akira, Sabari Joshua K

Abstract excerpt

BACKGROUND: Epidermal growth factor receptor (EGFR) exon 20 insertions (Ex20ins) are the third most common type of EGFR mutation, occurring in up to 12% of EGFR-mutated non-small cell lung cancers (NSCLC). Ex20ins-mutated NSCLC can be resistant to most approved tyrosine kinase inhibitors (TKIs). The Phase III PAPILLON trial (NCT04538664) demonstrated that amivantamab plus chemotherapy significantly improves...

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PMID: 41671629
DOI: 10.1016/j.lungcan.2025.108788

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