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Whole-exome sequencing for identification of genetic changes in adult-onset posterior polar cataract.

Indian journal of ophthalmology - 1 Jul 2026

Sharma Anshul, Sharma Namrata, Agarwal Tushar, Sharma Arundhati, Vajpayee Rasik B

Abstract excerpt

PURPOSE: Posterior polar cataract (PPC), a rare congenital cataract, is characterized by subcapsular opacities in the lens affecting vision and posing surgical challenges. Genetic heterogeneity exists, though several genes are implicated in its pathogenesis. This study reports on the genetic profile of late-onset PPC cases and identifies variations specific to posterior capsular rupture (PCR) during surgery....

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Age of Onset
Aged
Cataract
Crystallins
DNA
DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Exome Sequencing

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Open in PubMed Open full text

Identifiers

PMID: 41669784
DOI: 10.4103/IJO.IJO_2613_25
PMCID: PMC13422898

Genes

CRYBG3
GJA3
PITX3
CRYAB
CRYBA1
CRYGB
EPHA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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