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Increased epicardial adipose tissue is part of the phenotype of LMNA-associated partial lipodystrophy and could contribute to increased cardiovascular risk.

Diabetes & metabolism - 1 Nov 2025

Lamothe Sophie, Ancel Patricia, Belalem Inès, Lecaque Leïla, Fournel Joris, Jacquier Alexis, Houhou Zouhair, Julla Jean-Baptiste, Gautier Jean-François, Vigouroux Corinne, Gaborit Bénédicte, Vatier Camille

Abstract excerpt

LMNA-associated familial partial lipodystrophy (FPLD2) is characterized by limb lipoatrophy, cervicofacial and visceral abdominal lipohypertrophy, insulin resistance-related complications and early coronary artery disease (CAD), but epicardial adipose tissue (EAT) is poorly described. We aimed to characterize EAT as a potential new marker of cardiovascular risk in patients with FPLD2. Using a validated...

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Share to Cardiovascular Diseases
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Heart Disease Risk Factors

Share to Lamin Type A

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Source

Identifiers

PMID: 41623137
DOI: 10.1016/j.diabet.2025.101710

Genes

CAD
LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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