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BoGHV-4 Genotypic Diversity Shapes Inflammatory and Viral Gene Expression in Platelet-Rich Plasma-Supplemented Bovine Endometrial Cells.

Viruses - 31 Dec 2025

López Sofia, Álvarez Ignacio, Delgado Santiago, Andreoli Valentina, Urrutia Luna Naiara, Yavorsky Marisol, Pereyra Susana, Grolli Stefano, González Altamiranda Erika, Pérez Sandra, Verna Andrea

Abstract excerpt

Bovine gammaherpesvirus 4 (BoGHV-4) is an opportunistic uterine pathogen whose reactivation is associated with postpartum inflammation and bacterial lipopolysaccharide (LPS). Platelet-rich plasma (PRP) is a regenerative biotherapeutic capable of modulating inflammatory responses, although its effects may vary depending on BoGHV4 genotype. In this study, primary bovine endometrial cells (BECs) were cultured in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41600830
DOI: 10.3390/v18010064
PMCID: PMC12846352

Genes

CXCL8
TLR4
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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