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Article

Molecular Genetics of β-Cell Compensation in Gestational Diabetes Mellitus: Insights from CDKAL1, SLC30A8 and HHEX.

International journal of molecular sciences - 22 Jan 2026

Hryniewicka Justyna, Buczyńska-Backiel Angelika, Zbucka-Krętowska Monika, Krętowski Adam Jacek, Szelachowska Małgorzata

Abstract excerpt

Gestational diabetes mellitus (GDM) is a common metabolic complication of pregnancy associated with significant short- and long-term risks for both mother and offspring. Increasing evidence indicates that genetic susceptibility plays a central role in GDM pathogenesis, particularly through variants affecting insulin secretion and pancreatic β-cell function. This narrative review integrates molecular, clinical,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41596761
DOI: 10.3390/ijms27021121
PMCID: PMC12842414

Genes

CDKAL1
HHEX
SLC30A8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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