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Article

Wide Ranging Neurobehavioral Phenotype in Individuals With Costello Syndrome.

American journal of medical genetics. Part A - 1 May 2026

Curlee Millicent S, Siegel Atara, Little Paige, Toledo-Tamula Mary Anne, Martin Staci, Gross Andrea M, Yohe Marielle E, Aryavand Margarita, Frone Megan N, Ney Gina M, Stewart Douglas R, Wolters Pamela L

Abstract excerpt

Costello syndrome (CS) is a rare RASopathy that is typically associated with mild to moderate cognitive impairment. Based on detailed neuropsychological testing, this case series describes variability in the neurobehavioral presentations of three unrelated individuals with different pathogenic HRAS variants that cause CS. Results demonstrate a wide range of functioning among people with CS (extremely low to...

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Identifiers

PMID: 41578731
DOI: 10.1002/ajmga.70052
PMCID: PMC12879293

Genes

CS
HRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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