Novel metabolic adaptation driven by glycoside hydrolase family 25 protein contributes to increasing trimethoprim-sulfamethoxazole resistance in clinical human Brucella melitensis isolates in China.

Abstract excerpt

Brucellosis, caused by Brucella spp., is a globally zoonotic disease that results in substantial economic losses and public health concerns. Although antibiotic-resistant Brucella strains have been reported worldwide, the current status and underlying mechanisms of resistance among Chinese isolates remain poorly characterized. In this study, we analyzed 636 clinical human isolates of B. melitensis from China...

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• Anti-Bacterial Agents
• Brucella melitensis
• Brucellosis
• China
• Drug Resistance, Bacterial