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Population structure, regions of homozygosity (ROH) and selection signal of two domesitic goat breeds revealed by whole-genome resequencing.

BMC genomics - 20 Jan 2026

Han Mingxuan, Rong Youjun, Wang Xinle, Ao Xiaofang, Shang Fangzheng, Wang Zhiying, Su Rui, Wang Ruijun, Liu Yongbin, Zhang Yanjun

Abstract excerpt

BACKGROUND: Chinese indigenous goat breeds exhibit rich genetic diversity and a long history of domestication, endowing these native populations with superior traits in environmental adaptation, forage utilization, and disease resistance. The identification of selection signatures through comparative genomic analysis could facilitate the understanding of breed differentiation and enables the discovery of...

Topics

Animals
Homozygote
Goats
Whole Genome Sequencing
Selection, Genetic
Breeding
Phylogeny
Genetics, Population
Polymorphism, Single Nucleotide
Genomics
Genome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Principal Component Analysis

Genetic Variation

Source

Open in PubMed Open full text

Identifiers

PMID: 41559577
DOI: 10.1186/s12864-025-12418-8
PMCID: PMC12821903

Genes

PDGFD
TGFBR3
BMPER
GALNTL6
NBEA
CACNA2D1
CDH23
CNGB3
CTNNA1
DCHS2
DGKB
MAP3K3
MED13
SHROOM3
SIL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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