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Complex Genetics in Somatic Mosaic Disorders: Evaluating the Rate of Multiple "Hits" in Nonmalignant Lesions.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Mar 2026

Nguyen Brian, Gillentine Madelyn A, Myers Candace T, Bhatia Sofia, Narayanan Jaya, Rogge Larissa, Emery Louisa, Perkins Jonathan, Eng Whitney, Wandler Anica, Paschal Cate R, Bennett James T, Nelson Nya D

Abstract excerpt

Vascular anomalies encompass a heterogeneous group of vascular tumors and malformations and are most often caused by singular somatic variants that arise in utero. The presence of multiple variants, including those in at least 2 different genes (multigenic variants), is rare in these mosaic disorders, and their contribution to histology and phenotype has not been well characterized. We present our molecular and...

Topics

Humans
Mosaicism
Female
Retrospective Studies
Male
Phenotype
Vascular Malformations
Adult
Child
Adolescent

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Predisposition to Disease

Child, Preschool

Young Adult

Middle Aged

Infant

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Identifiers

PMID: 41544971
DOI: 10.1016/j.modpat.2026.100962

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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