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Emergence and epidemiology of dominant variants of human metapneumovirus in the United States between 2016 and 2021.

mBio - 11 Feb 2026

Pless Lora Lee, Damodaran Lambodar, Pomponio Ray, Patrick Rose, Griffith Marissa Pacey, Walters Sara, Waggle Kady D, Pleskovitch Atalia, Rangachar Srinivasa Vatsala, Varela Cole A, Harrison Lee H, Barton John P, Moncla Louise H, Michaels Marian G, Williams John V, Wang-Erickson Anna F

Abstract excerpt

Human metapneumovirus (HMPV) causes acute respiratory disease worldwide and is the second leading cause of lower respiratory infection and hospitalization in young children in the USA. There is no licensed vaccine or therapeutic. HMPV mutates rapidly; however, the specific genomic features that explain strain dominance remain undefined because there is limited routine genomic surveillance of HMPV. We analyzed...

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Identifiers

PMID: 41524405
DOI: 10.1128/mbio.02619-25
PMCID: PMC12892982

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