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Development and optimization of the hypoglycemic activity of an α-glucosidase inhibitory protein from a UV-induced mutant strain of Streptomyces griseorubens.

Protein expression and purification - 1 May 2026

Alosaimi Mohammed, Abdulkhair Waleed, Asseri Jamal, Almuqrin Abdulmajeed, AlMalki Fatemah

Abstract excerpt

This study investigated the isolation, enhancement, and optimization of an α-glucosidase inhibitory protein with hypoglycaemic activity from Streptomyces species obtained from tomato-cultivated soils rich in actinomycetes. A total of 110 Streptomyces isolates were recovered from ten soil samples collected in Sakha City. Sixteen isolates exhibited notable α-glucosidase inhibitory activity, with isolate Strep-5...

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PMID: 41512981
DOI: 10.1016/j.pep.2026.106878

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