Early life-stage thermal resilience is determined by climate-linked regulatory variation.

doi:10.1073/pnas.2518358123

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Article

Early life-stage thermal resilience is determined by climate-linked regulatory variation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2026

Nunez Joaquin C B, Tangwancharoen Sumaetee, Finnegan Kylie M, Bufferd Eliza M, King Olin C, Proud Luke A, Lockwood Brent L

Abstract excerpt

The ecological context of developmental physiology remains largely unexplored. We previously showed that thermal selection primarily targets early embryos in Drosophila melanogaster. Here, we used advanced introgression and pooled whole-genome resequencing to map the genomic basis of enhanced embryonic heat tolerance in a neotropical line of D. melanogaster. We identified two loci on chromosomes 2R and X that...

Topics

Animals
Drosophila melanogaster
Thermotolerance
Polymorphism, Single Nucleotide
Selection, Genetic
Drosophila Proteins
Climate

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Identifiers

PMID: 41505517
DOI: 10.1073/pnas.2518358123
PMCID: PMC12799179

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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