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Article

Synergistic use of 1,5-AG and HbA1c for early prediction of gestational diabetes: capturing BMI-dependent glycemic phenotypes.

Archives of gynecology and obstetrics - 2 Jan 2026

Tano Sho, Inamura Tatsuo, Fuma Kazuya, Matsuo Seiko, Imai Kenji, Katsuki Satoru, Kishigami Yasuyuki, Oguchi Hidenori, Kotani Tomomi, Ushida Takafumi, Kajiyama Hiroaki

Abstract excerpt

PURPOSE: Recognizing metabolic heterogeneity in gestational diabetes mellitus (GDM) and body mass index (BMI)-linked phenotypes, we evaluated whether combining hemoglobin A1c (HbA1c, reflecting fasting glycaemia) and 1,5-anhydroglucitol (1,5-AG, reflecting post-load glucose excursions) improves early prediction and whether performance differs by BMI. METHODS: In this multicenter retrospective study, pregnant...

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Identifiers

PMID: 41483238
DOI: 10.1007/s00404-025-08281-3
PMCID: PMC12764630

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