Article
Loss of virulence of Botrytis cinerea mutants defective in phytotoxin production is restored by modifying inoculation medium.
mBio - 11 Feb 2026
Qin Si, Shi-Kunne Xiaoqian, Chen Jie, Pieterse Frank P J, Beenen Henriek G, You Yaohua, van Kan Jan A L
Abstract excerpt
Botrydial, botcinic acid, and their derivatives are major phytotoxic metabolites produced by the necrotrophic fungal pathogen Botrytis cinerea. These phytotoxins are able to induce programmed cell death in the host and thereby promote plant susceptibility to B. cinerea. We observed that a ∆bot2∆boa6 double-mutant strain, which synthesizes neither botrydial nor botcinic acid, was almost avirulent on tomato leaves...
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