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Article

Irritability in autism examined through network analysis of phenotypic and physiological correlates.

Scientific reports - 24 Dec 2025

Alatrash Sara, Paul Tithi, Andrade Brendan F, Monga Suneeta, Brian Jessica, Anagnostou Evdokia, Penner Melanie, Fekr Atena Roshan, Kushki Azadeh

Abstract excerpt

Symptoms of irritability are commonly reported in autism, yet correlates of this domain remain poorly understood. While prevalence estimates in the literature vary considerably, they range up to 80%. Irritability can interfere with daily functioning, social relationships, and academic performance. Despite years of research and the availability of approved medications, intervention outcomes for irritability remain...

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PMID: 41444737
DOI: 10.1038/s41598-025-28408-5
PMCID: PMC12738722

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