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Article

Clinical characteristics and treatment of EGFR exon 19 L747 mutation in advanced NSCLC: a retrospective study.

BMC cancer - 22 Dec 2025

Yang Yifan, Kong Shengnan, Hei Yue, Yang Ruixia, Wang Xin, Wang Xinyi, He Chunhong, Zhang Hongmei, Chen Yan

Abstract excerpt

BACKGROUND: This study investigates the clinical characteristics, targeted therapy outcomes, co-mutations, and prognosis of lung cancer patients with EGFR exon 19 (ex19) L747 mutations in Northwest China, providing insights for treating these rare mutations. METHODS: We retrospectively analyzed advanced NSCLC patients with EGFR ex19 L747 mutations, identified from January 2020 to August 2024 at Xijing Hospital,...

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Identifiers

PMID: 41430146
DOI: 10.1186/s12885-025-15451-8
PMCID: PMC12836831

Genes

EGFR
TP53
BRCA1
MED12
RB1
SMARCA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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