Exploratory analysis of gene aberrations and chemotherapy response: findings from a real-world database in Japan.

Abstract excerpt

BACKGROUND: Chemotherapy selection traditionally relies on tumor tissue of origin. However, since genetic alterations drive tumor behavior, it remains unclear if mutations can better predict response. We hypothesized that genetic aberrations might influence chemotherapy outcomes more than tissue origin. METHODS: We retrospectively analyzed 15,474 Japanese patients with solid tumors who underwent comprehensive...

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• Aged
• Aged, 80 and over
• Antineoplastic Agents
• APC gene
• Japan