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Article

MAP4K1 and MAP4K2 regulate ABA-induced and Ca2+-mediated stomatal closure in Arabidopsis.

Science advances - 19 Dec 2025

Yamashita Kota, Katagiri Sotaro, Takase Hinano, Li Yangdan, Oishi Anzu, Otoguro Airi, Kamiyama Yoshiaki, Yamauchi Shota, Wang Yuh-Shuh, Takemiya Atsushi, Mori Izumi C, Kollist Hannes, Umezawa Taishi

Abstract excerpt

Abscisic acid (ABA)-induced stomatal closure limits water loss from plants under drought stress. To investigate the signaling pathways involved in ABA-induced stomatal closure, we performed a phosphoproteomic analysis of ABA-treated Arabidopsis guard cell protoplasts (GCPs). We found that ABA-responsive phosphorylation of MITOGEN-ACTIVATED PROTEIN 4 KINASE 1 (MAP4K1) was significantly down-regulated in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41417897
DOI: 10.1126/sciadv.adt4916
PMCID: PMC12716388

Genes

MAP4K1
MAP4K2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

MAP4K1 and MAP4K2 regulate ABA-induced and Ca2+-mediated stomatal closure in Arabidopsis.PMID 41417897Read ↗

ABA-activated SnRK2 protein kinase is required for dehydration stress signaling in Arabidopsis.Semantic proximity Read ↗

MAP3Kinase-dependent SnRK2-kinase activation is required for abscisic acid signal transduction and rapid osmotic stress response.Semantic proximity Read ↗

Pohsphorylation of MAP4K1 and MAP4K2 by OST1 is required for drought tolerance.Semantic proximity Read ↗

Arabidopsis ABA-Activated Kinase MAPKKK18 is Regulated by Protein Phosphatase 2C ABI1 and the Ubiquitin-Proteasome Pathway.Semantic proximity Read ↗

The structure of Arabidopsis thaliana OST1 provides insights into the kinase regulation mechanism in response to osmotic stress.Semantic proximity Read ↗

Open Stomata 1 (OST1) is limiting in abscisic acid responses of Arabidopsis guard cells.Semantic proximity Read ↗

The regulatory domain of SRK2E/OST1/SnRK2.6 interacts with ABI1 and integrates abscisic acid (ABA) and osmotic stress signals controlling stomatal closure in Arabidopsis.Semantic proximity Read ↗

Identification of Open Stomata1-Interacting Proteins Reveals Interactions with Sucrose Non-fermenting1-Related Protein Kinases2 and with Type 2A Protein Phosphatases That Function in Abscisic Acid Responses.Semantic proximity Read ↗

MAP kinases MPK9 and MPK12 are preferentially expressed in guard cells and positively regulate ROS-mediated ABA signaling.Semantic proximity Read ↗

Aquaporins Contribute to ABA-Triggered Stomatal Closure through OST1-Mediated Phosphorylation.Semantic proximity Read ↗

bHLH transcription factors that facilitate K⁺ uptake during stomatal opening are repressed by abscisic acid through phosphorylation.Semantic proximity Read ↗

Two Arabidopsis guard cell-preferential MAPK genes, MPK9 and MPK12, function in biotic stress response.Semantic proximity Read ↗

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