Article
A novel multimodal diagnostic framework integrating hyperspectral imaging and deep learning for predicting RET gene mutations in medullary thyroid carcinoma.
Computer methods and programs in biomedicine - 1 Feb 2026
Yang Zhenpeng, Su Peng, Zhang Yuyang, Zheng Haitao, Deng Yupeng, Lin Xiangfeng, Ding Changyuan, Li Wei, Liang Weili, Lv Bin
Abstract excerpt
BACKGROUND AND OBJECTIVE: Medullary thyroid carcinoma (MTC) is an aggressive malignancy driven predominantly by activating mutations in the RET proto-oncogene. Conventional genotyping using polymerase chain reaction (PCR) or next-generation sequencing (NGS) is often hampered by burdensome costs and prolonged turnaround times, hindering timely clinical decision-making. METHODS: We developed a rapid,...
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