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Article

Phenotypic and genotypic differences between bloodstream and non-blood Candida krusei isolates: implications for invasiveness and antifungal susceptibility.

Microbiology spectrum - 6 Jan 2026

Zhao Ying, Wang Han, Yu Jinhan, Li Yi, Zhang Ge, Kang Wei, Xiao Meng, Yang Qiwen, Guo Lina, Xu Yingchun

Abstract excerpt

Candida krusei is an opportunistic pathogen with intrinsic resistance to fluconazole. This study analyzed 174 C. krusei isolates from bloodstream infections (BSI, n = 115) and non-blood sources (n = 59). Biochemical profiling using the VITEK 2 YST ID Card revealed a significant difference in the TyrA reaction between BSI and non-blood isolates (P < 0.05). Antifungal susceptibility testing via CLSI broth...

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Identifiers

PMID: 41347501
DOI: 10.1128/spectrum.02608-25
PMCID: PMC12772365

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