Article
Engineering seed-specific gossypol-free cotton for human-safe consumption by harnessing the dominant-negative effect of the Gl2e mutation.
Plant communications - 9 Feb 2026
Cheng Xiangfei, Wang Pengbao, Wang Xinchun, Zameer Roshan, Liu Lu, Chen Zhouqing, Wang Pengyu, Jiang Jing, Yu Chengde, Tian Baoliang, Wang Wei, Yu Shunhe, Pan Hui, Shi Huazhong, Duan Cheng-Guo, Zuo Dongyun, Zhao Lihong, Li Zhifang, Song Chun-Peng, Song Guoli, Zou Changsong
Abstract excerpt
The global yield of cottonseed could meet the annual protein requirements of approximately half a billion people if gossypol were absent from the seeds. Here, we characterize the molecular mechanism by which the Gl2e mutation exerts a dominant-negative effect on gland development, providing a mechanistic basis for engineering seed-specific gossypol-free (SSGF) cotton. We show that Gl2/Gl3 form multimers-likely...
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