Development of surface-enhanced Raman scattering nanoprobes for the simultaneous multiplex detection of characteristic DNA sequences: case studies of pathogenic Vibrio parahaemolyticus and Apolipoprotein E gene polymorphisms.

Abstract excerpt

Relying on a single biomarker in biomedical analysis is often insufficient for accurate disease or pathogen determination. A recent trend is using simultaneous multiplex detection of multiple biomarkers to improve diagnostic accuracy and throughput. To enable multiplex detection, we developed a series of surface-enhanced Raman scattering (SERS) nanoprobes, referred to as nanoaggregate-embedded beads (NAEBs)....

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