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Echinocandin-resistant Candida albicans: A case report from Japan.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Dec 2025

Hikida Sayaka, Akiyama Yutaro, Ishikane Masahiro, Shimazu Hiroshi, Nasu Ryo, Shinohara Takayuki, Nagi Minoru, Shirai Rei, Onakado Makiko, Nakayama Nobuko, Miyazaki Yoshitsugu, Hangaishi Akira, Ohmagari Norio

Abstract excerpt

Echinocandin-resistant Candida albicans (C. albicans) is a rare but increasing global concern. In Japan, at least three cases had been confirmed by the end of 2015. Mutations in FKS cause echinocandin resistance in Candida species, which is primarily driven by previous echinocandin antifungal use. C. albicans resistance to echinocandins is raising clinicians' concerns globally and could pose a threat to Japan in...

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PMID: 41207373
DOI: 10.1016/j.jiac.2025.102856

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