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Article

VEXAS syndrome presenting with features of Sjögren's disease: a case-based review of VEXAS and autoimmune disease overlap.

Clinical rheumatology - 1 Jan 2026

Groener Marwin, Baker Hailey, Danve Abhijeet

Abstract excerpt

VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic syndrome) is an adult-onset autoinflammatory disorder caused by somatic mutations in the UBA1 gene. While its clinical spectrum is expanding, the overlap with autoimmune diseases remains poorly characterized. We present the first reported case of VEXAS featuring overlap with Sjögren's disease. An 86-year-old man with myelodysplastic syndrome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41193889
DOI: 10.1007/s10067-025-07773-6

Genes

UBA1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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VEXAS syndrome presenting with features of Sjögren's disease: a case-based review of VEXAS and autoimmune disease overlap.PMID 41193889Read ↗

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Clinical characteristics, disease trajectories and management of vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) syndrome: a systematic review.Semantic proximity Read ↗

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