A novel anticancer natural product SP09 selectively targets KRAS-mutant NSCLC through LKB1/AMPK/mTOR modulation: implications for novel therapeutic development.

doi:10.1097/CAD.0000000000001773

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Article

A novel anticancer natural product SP09 selectively targets KRAS-mutant NSCLC through LKB1/AMPK/mTOR modulation: implications for novel therapeutic development.

Anti-cancer drugs - 1 Feb 2026

Yue Peng, Hon Chitin, Zhao Xiaoping, Ali Fayaz, Sun Jiayi, Kou Jiyou

Abstract excerpt

KRAS -mutant non-small cell lung cancer (NSCLC) remains a major therapeutic challenge due to the paucity of effective targeted agents. Although covalent KRAS^G12C inhibitorsi such as sotorasib and adagrasib have demonstrated clinical activity, pooled analyses indicate only modest response rates and short progression-free survival, with no effective options for non-G12C subtypes. This highlights the need for novel...

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Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Proto-Oncogene Proteins p21(ras)
AMP-Activated Protein Kinase Kinases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

TOR Serine-Threonine Kinases

Protein Serine-Threonine Kinases

AMP-Activated Protein Kinases

Cell Proliferation

Mutation

Antineoplastic Agents

Cell Line, Tumor

Signal Transduction

Source

Open in PubMed Open full text

Identifiers

PMID: 41191614
DOI: 10.1097/CAD.0000000000001773
PMCID: PMC12736418

Genes

KRAS
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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