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Article

The cryptic diversity of hepadnavirus relatives.

mBio - 10 Dec 2025

Gong Zhen, Han Guan-Zhu

Abstract excerpt

Enveloped hepadnaviruses, non-enveloped nackednaviruses, and the recently discovered non-enveloped proto-nackednaviruses are closely related reverse-transcribing DNA viruses. Yet, the host range and diversity of proto-nackednaviruses remain unclear. Here, we report the discovery of 31 proto-nackednaviruses (PnNVs) through deep genome-scale data mining. PnNVs are predominantly identified in distinct species of...

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Identifiers

PMID: 41186230
DOI: 10.1128/mbio.02541-25
PMCID: PMC12691608

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