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Article

Synergistic regulation of fibroblast phenotype by high-dose estrogen and matrix stiffness: implications for intrauterine adhesion therapy†.

Biology of reproduction - 11 Jan 2026

Su Ying, Yan Song, Zhang Wanlin, Li Wenyi, Sun Dan, Yang Fang, Wang Qiwen, Mu Hui, Lu Jie, Chen Shuqiang, Wang Xiaohong

Abstract excerpt

Intrauterine adhesion (IUA) is a leading cause of uterine infertility and often recurs post surgery due to limited treatments. Although estrogen is widely used to prevent recurrence, its efficacy remains unclear. A key characteristic of IUA is the excessive production of extracellular matrix (ECM) by activated myofibroblasts, which disrupts normal endometrial mechanics. Whether estrogen and ECM stiffness...

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PMID: 40971508
DOI: 10.1093/biolre/ioaf208

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