Article
Fully Automated Image-Based Multiplexing of Serial PET/CT Imaging for Facilitating Comprehensive Disease Phenotyping.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine - 3 Nov 2025
Shiyam Sundar Lalith Kumar, Gutschmayer Sebastian, Pires Manuel, Ferrara Daria, Nguyen Toni, Abdelhafez Yasser Gaber, Spencer Benjamin, Cherry Simon R, Badawi Ramsey D, Kersting David, Fendler Wolfgang P, Kim Moon-Sung, Lassen Martin Lyngby, Hasbak Philip, Schmidt Fabian, Linder Pia, Mu Xingyu, Jiang Zewen, Abenavoli Elisabetta M, Sciagrà Roberto, Frille Armin, Wirtz Hubert, Hesse Swen, Sabri Osama, Bailey Dale, Chan David, Callahan Jason, Hicks Rodney J, Beyer Thomas
Abstract excerpt
Combined PET/CT imaging provides critical insights into both anatomic and molecular processes, yet traditional single-tracer approaches limit multidimensional disease phenotyping; to address this, we developed the PET Unified Multitracer Alignment (PUMA) framework-an open-source, postprocessing tool that multiplexes serial PET/CT scans for comprehensive voxelwise tissue characterization. Methods: PUMA utilizes...
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