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Article

High-impact pain predicts subjective cognitive decline and interacts with APOE4 genotype in the development of objective cognitive impairment.

The journal of pain - 1 Dec 2025

Tamargo Javier A, Smith Glenn, Chen Li, Cruz-Almeida Yenisel

Abstract excerpt

Chronic pain is the most common health challenge for older adults and a significant risk factor for cognitive impairments and dementia. This study examined the relationship of high-impact pain (i.e., pain that limits daily activities) with subjective cognitive decline (SCD) and objective cognitive impairment in 13,763 adults aged 50 and older from the Health and Retirement Study (2004-2020). High-impact pain was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40967388
DOI: 10.1016/j.jpain.2025.105564
PMCID: PMC13178934

Genes

SCD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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