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Article

Metabolically Abnormal Obesity and Carotid Plaque Vulnerability: A Vessel Wall MRI Study Linking Obesity Phenotypes to Atherosclerotic Instability.

Arteriosclerosis, thrombosis, and vascular biology - 1 Nov 2025

Shao Sai, Sun Yan, Shi Honglu, Li Rui, Sun Qinjian, Yao Bin, Watase Hiroko, Hippe Daniel S, Yuan Chun, Wang Guangbin, Zhang Quan, Zhao Xihai

Abstract excerpt

BACKGROUND: Carotid plaque vulnerability, driven by metabolic dysfunction and obesity, is a critical determinant of ischemic stroke risk. However, the heterogeneity of obesity phenotypes-defined by metabolic health-remains underexplored in cardiovascular risk stratification. Therefore, this study employs high-resolution magnetic resonance vessel wall imaging to assess differences in high-risk carotid plaque...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40964717
DOI: 10.1161/ATVBAHA.125.323413
PMCID: PMC12542998

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