Export by a quorum sensing-controlled drug exporter underlies rifampicin's strong activity against staphylococcal biofilms.

Abstract excerpt

Biofilm infections on indwelling medical devices are a major cause of health care-associated infection and mortality. Most of these infections are caused by staphylococci. Biofilm formation presents a continued clinical challenge because of the association with dramatically increased nonspecific antimicrobial resistance. Unlike most antibiotics, rifampicin is active against staphylococcal biofilm infections;...

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