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Article

Investigating Macular Tissue Integrity Index as a Novel Biomarker in Geographic Atrophy

2 Jul 2025

Abstract excerpt

Purpose: The rate of geographic atrophy (GA) enlargement is commonly used as an outcome in clinical trials. However, this metric typically lacks specificity for central macular involvement and structure-function relationships. We propose a targeted approach in monitoring GA progression within the central macula, highlighting the limited benefit of including GA expansion beyond the 3-mm perifoveal zone when...

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PMID: 40893624
DOI: 10.1016/j.xops.2025.100871

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