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Article

MAP1B Variants Disrupt Neuronal Migration: Insights From Three Novel Families.

Clinical genetics - 1 Mar 2026

Archer Jessica, Edwards Matt, Macdougall Thomas, Baxter Anne, Goel Himanshu

Abstract excerpt

MAP1B (microtubule-associated protein 1B) encodes a cytoskeletal regulator critical for neuronal migration, axon guidance, and cortical circuit formation. Disease-causing variants (DCVs) in MAP1B have recently emerged as a cause of neurodevelopmental disorders characterized by intellectual disability, epilepsy, and cortical malformations, including periventricular nodular heterotopia (PVNH) and polymicrogyria...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40874586
DOI: 10.1111/cge.70059
PMCID: PMC12881218

Genes

MAP1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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MAP1B Variants Disrupt Neuronal Migration: Insights From Three Novel Families.PMID 40874586Read ↗

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