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Hypoxia boosts pluripotent-like muse cell ratio in mesenchymal stromal cells and upregulates the pluripotency gene expression

25 Aug 2025

Abstract excerpt

Muse cells are SSEA-3-positive pluripotent-like endogenous stem cells found in various tissues, including peripheral blood and organ connective tissue. Their reserve is considered the hypoxic bone marrow. In mesenchymal stromal cell (MSC) cultures, Muse cells comprise several percent of the population. Clinical trials using intravenous administration of Muse cells without genetic modification or differentiation...

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PMID: 40854920
DOI: 10.1038/s41598-025-03806-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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