Article
Progressive respiratory failure in a term neonate with ABCA3 surfactant deficiency: Beyond the common causes of respiratory distress.
Journal of neonatal-perinatal medicine - 1 Mar 2026
Beverstock Andrew M, Lee Hillary C, McNeill David S Moreno, Hanna Morcos
Abstract excerpt
BackgroundMost cases of respiratory distress in term neonates are due to transient tachypnea of the newborn (TTN), respiratory distress syndrome (RDS), or air leak syndromes. Genetic surfactant deficiencies are rare causes of respiratory distress. Among these, mutations in the ABCA3 gene disrupt surfactant metabolism and can lead to severe, treatment-refractory respiratory failure. While commonly considered in...
Topics
- Humans
- Female
- Infant, Newborn
- ATP-Binding Cassette Transporters
- Respiratory Distress Syndrome, Newborn
- Pulmonary Surfactants
- Respiratory Insufficiency
- Continuous Positive Airway Pressure
- Mutation
- Lung Diseases, Interstitial