Sequential versus massively parallel strategies for molecular characterization of non-small cell lung cancer samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration.

doi:10.36416/1806-3756/e20250039

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Article

Sequential versus massively parallel strategies for molecular characterization of non-small cell lung cancer samples obtained by endobronchial ultrasound-guided transbronchial needle aspiration.

Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia - 1 Jan 2025

Rodrigues Luís Vaz, Viegas Marta, Ladeirinha Ana Filipa, Alarcão Ana, Taborda-Barata Luis, Cordovilla Rosa, Sousa Vitor

Abstract excerpt

OBJECTIVES: The advent of massively parallel next-generation sequencing (MP-NGS) offers potential advantages over sequential molecular profiling (SMP) in the management of non-small cell lung cancer (NSCLC). This study compares the two methodologies using samples obtained through endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), focusing on actionable mutation detection, turnaround...

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Topics

Humans
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Retrospective Studies
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Female

Endoscopic Ultrasound-Guided Fine Needle Aspiration

Middle Aged

Aged

High-Throughput Nucleotide Sequencing

Mutation

Time Factors

Aged, 80 and over

Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 40834134
DOI: 10.36416/1806-3756/e20250039
PMCID: PMC12401144

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