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Integrating bioinformatics and machine learning to elucidate the role of protein glycosylation-related genes in the pathogenesis of diabetic kidney disease

18 Aug 2025

Abstract excerpt

BACKGROUND: Diabetic kidney disease (DKD) is a severe global complication of diabetes, yet its molecular mechanisms remain incompletely understood. This study aimed to investigate the role of protein glycosylation in DKD pathogenesis and its association with gene expression changes, with the goal of identifying diagnostic biomarkers and personalized therapeutic targets. METHODS: Integrated bioinformatics and...

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PMID: 40825025
DOI: 10.1371/journal.pone.0329640

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