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LiaS gene from two-component system is essential for caries pathogenicity in dual-species biofilms of Streptococcus mutans and Candida albicans

31 Jul 2025

Abstract excerpt

Introduction This study elucidated the critical role of the liaS gene in the Streptococcus mutans (S. mutans) two-component signal (TCS) transduction system during cross-kingdom interactions with Candida albicans (C. albicans). This gene governs the cariogenic potential of dual-species biofilms. Methods Gene expression analysis of cocultured samples was performed. The survival rate during H2O2 treatment in single...

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PMID: 40822408
DOI: 10.3389/fmicb.2025.1612841

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