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Epilepsy in NHS actin remodeling regulator gene (NHS) and genotype-phenotype correlations.

Pediatric research - 1 Feb 2026

Zhang Kai-Li, Wang Jie, Tang Zhi-Hong, Zhai Qiong-Xiang, Peng Yuan-Yuan, Li Bing-Mei, Liu Xiao-Rong, Peng Qian, Li Bin, Liao Wei-Ping

Abstract excerpt

BACKGROUND: NHS gene encodes a protein with four conserved nuclear localization signals that regulates actin assembly and cell spreading. NHS variants are associated with cataract-related disorders with/without seizures. However, the NHS-epilepsy association remains unclear. METHODS: Trio-based whole-exome sequencing was performed in patients with epilepsy of unknown cause. Previously reported variants were...

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PMID: 40817290
DOI: 10.1038/s41390-025-04335-z

Genes

NHS
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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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