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Gut microbiota links to cognitive impairment in bipolar disorder via modulating synaptic plasticity

12 Aug 2025

Abstract excerpt

BACKGROUND: Cognitive impairment is an intractable clinical manifestation of bipolar disorder (BD), but its underlying mechanisms remain largely unexplored. Preliminary evidence suggests that gut microbiota can potentially influence cognitive function by modulating synaptic plasticity. Herein, we characterized the gut microbial structure in BD patients with and without cognitive impairment and explored its...

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PMID: 40797316
DOI: 10.1186/s12916-025-04313-6

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