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Article

Mediated pleiotropy drives the negative correlation of total carotenoid and dry matter contents in cassava (Manihot esculenta).

Genetics - 8 Oct 2025

Villwock Seren S, Parkes Elizabeth Y, Mbanjo Edwige Gaby Nkouaya, Rabbi Ismail Y, Jannink Jean-Luc

Abstract excerpt

Plant breeders aim to increase provitamin A carotenoids in cassava (Manihot esculenta) storage roots to help combat vitamin A deficiency in sub-Saharan Africa, but a negative genetic correlation between total carotenoid and dry matter contents hinders progress. While genetic linkage between a major-effect variant in the phytoene synthase 2 (PSY2) gene and nearby candidate gene(s) has been thought to drive this...

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Identifiers

PMID: 40796123
DOI: 10.1093/genetics/iyaf162
PMCID: PMC12505300

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